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pentobarbital will reduce the level or result of pitolisant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Pitolisant exposure is diminished by 50% if coadministered with strong CYP3A4 inducers.pentobarbital will reduce the extent or impact of alprazolam by impacting hepatic/intestinal enzyme CYP3A4 metabo